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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
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Rationalizing nose-to-brain drug delivery: Machine learning-guided optimization and mechanistic elucidation of

Zizhao Zhai1, Wenhao Wang2, Guanlin Wang2

  • 1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, Guangdong, PR China; College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, PR China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|January 30, 2026
PubMed
Abstract

Keywords:
Dispersed mediumMachine learningNose-to-brain drug deliveryOlfactory depositionSolid lipid nanoparticles

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