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Updated: Feb 1, 2026
Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
Published on: September 25, 2018
Tumor Location Significantly Correlates With PD-L1 Status in Patients With Small Sized Non-small Cell Lung Cancer
Takuma Tsukioka1, Ryu Nakajima2, Kyukwang Chung2
1Department of General Thoracic Surgery, Osaka City General Hospital, Osaka, Japan t-tukioka@med.osakacity-ho.or.jp.
Background/Aim:
Predicting programmed death-ligand 1 (PD-L1) expression in resectable lung cancer cases is highly significant for establishing treatment strategies. Although there were differences in tumor characteristics between central and peripheral lesions in non-small cell lung cancer (NSCLC), the relationship between tumor location and PD-L1 expression status has not been examined. We investigated the relationship between clinical background factors, including tumor location, and PD-L1 expression status.
Patients And Methods:
A total of 245 NSCLC patients whose tumors were measuring 3 cm or less in diameter and had a consolidation tumor ratio (CTR) <0.5 were included in this study. A tumor was classified as peripheral if its location was in the outer one-third of the computed tomography horizontal section, and as central otherwise. PD-L1 immunohistochemistry was performed using 22C3 antibody. PD-L1 expression status were categorized as negative [PD-L1 tumor proportion score (TPS) <1%] and as positive (PD-L1 TPS ≥1%).
Results:
Statistically significant differences were identified in CTR (p=0.006), histology type (p<0.001) and tumor location (p=0.036) according to the PD-L1 expression status. A greater proportion of patients with a smoking history were observed in the PD-L1 expression positive group (p=0.076). Multivariate analysis revealed 0.94< CTR (p=0.033), non-adenocarcinoma (p=0.018) and central lesion (p=0.034) were independent predictive factors for positive PD-L1 expression status. A predictive scoring system incorporating these three factors demonstrated a stepwise increase in PD-L1 positivity with higher scores.
Conclusion:
PD-L1 expression status significantly correlated with CTR, histological type and tumor location. This is the first report demonstrating a significant correlation between PD-L1 expression and tumor location in NSCLC. We believe that differences in the cancer microenvironment based on tumor location influence PD-L1 expression status in cancer cells.
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