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Related Experiment Video

Updated: Feb 1, 2026

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy
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Radiotherapy Strategies for Stage II Breast Cancer With Lymphovascular Invasion After Mastectomy.

Shuang Gao1, Xueqiao Yu1, Yang Li1

  • 1Department of Breast Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, P.R. China.

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|January 30, 2026
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Summary

Postmastectomy radiotherapy (PMRT) improves local control and disease-free survival (DFS) for early-stage breast cancer patients with lymphovascular invasion (LVI). PMRT offers survival benefits for LVI-positive patients achieving ypN0 status after neoadjuvant chemotherapy (NAC).

Keywords:
Breast cancerclinical decision-makinglymphovascular invasionprognosisradiotherapy

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Area of Science:

  • Oncology
  • Radiotherapy
  • Breast Cancer Research

Background:

  • Lymphovascular invasion (LVI) is a significant prognostic indicator in breast cancer, correlating with poorer survival outcomes.
  • The precise clinical benefit of postmastectomy radiotherapy (PMRT) in early-stage breast cancer patients with LVI remains an area of ongoing investigation.
  • Real-world data is crucial for evaluating the efficacy of PMRT and identifying associated prognostic factors in diverse patient populations.

Purpose of the Study:

  • To evaluate the efficacy of postmastectomy radiotherapy (PMRT) in improving survival outcomes for breast cancer patients with lymphovascular invasion (LVI).
  • To identify prognostic factors influencing treatment response and survival in this patient cohort.
  • To assess the impact of adjuvant radiotherapy on local recurrence-free survival (LRFS), disease-free survival (DFS), overall survival (OS), and distant DFS (DDFS).

Main Methods:

  • Retrospective analysis of 322 breast cancer patients with confirmed LVI who received radiotherapy (RT) between October 2017 and July 2020.
  • Patients were stratified into two groups: Group A (pT1-2N1M0) and Group B (stage II, ypN0 after neoadjuvant chemotherapy and surgery).
  • Kaplan-Meier analysis was employed to estimate survival endpoints, including LRFS, DFS, OS, and DDFS.

Main Results:

  • In Group A, adjuvant RT significantly improved 5-year LRFS and DFS compared to no RT (p<0.05).
  • In Group B, adjuvant RT significantly improved 5-year DFS, OS, and DDFS for patients with ypN0 status (p<0.05).
  • Subgroup analysis in Group A revealed higher recurrence risk in patients with two to three positive lymph nodes or triple-negative tumors.

Conclusions:

  • Adjuvant radiotherapy enhances local control and disease-free survival in stage II LVI-positive breast cancer patients, though not overall survival.
  • PMRT demonstrates survival benefits for LVI-positive patients who achieve ypN0 status post-neoadjuvant chemotherapy, supporting its recommendation.
  • Further extensive studies are warranted to corroborate these findings and refine treatment strategies for LVI-positive breast cancer.