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Updated: Feb 1, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light-Driven Copper Catalysis: A Green and Sustainable Approach to Chlorohydroxylation of Chalcones
Qi Shi1, Dong-Xiang Li1, Xing-Lan Wang1
1School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
Abstract:
This work reports a green and sustainable method of chlorohydroxylation of chalcone derivatives via visible-light-induced copper catalysis under room temperature conditions to chemoselectively convert chalcones into the corresponding chlorohydrins. This approach enables the efficient conversion of various chalcone derivatives with electron-withdrawing and electron-donating groups. Preliminary mechanistic studies indicated that chlorine radical (Cl·) generated through the ligand-to-metal charge transfer process can promote the efficient construction of chlorohydrin structures.
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