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Updated: Feb 1, 2026

Author Spotlight: Establishing a Murine Non-Small Cell Lung Cancer Model for Developing Nanoformulations of Anticancer Drugs
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RORγ drives non-small cell lung cancer progression by upregulating the NGF signaling

Yechun Zeng1, Guodi Cai1, Jian Zhang2

  • 1National-Local Joint Engineering Laboratory of Druggability and New Drugs Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510006, China.

Respiratory Research
|January 31, 2026
PubMed
Abstract

Insights

Retinoic acid receptor-related orphan receptor gamma (RORγ) drives non-small cell lung cancer (NSCLC) progression by promoting cell proliferation and metastasis. Inhibiting RORγ, a key regulator, offers a promising therapeutic strategy for NSCLC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality worldwide.
  • Novel therapeutic targets are urgently needed for effective NSCLC treatment.
  • The role of retinoic acid receptor-related orphan receptor gamma (RORγ) in NSCLC remains largely undetermined.

Purpose of the Study:

  • To investigate the role and mechanism of RORγ in the progression of NSCLC.
  • To evaluate RORγ as a potential therapeutic target for NSCLC.

Main Methods:

  • Bioinformatics analysis, immunohistochemistry, and Western blot were used to assess RORγ expression in NSCLC.
  • In vitro and in vivo assays were performed to determine the functional roles of RORγ in NSCLC proliferation, migration, and invasion.
  • RNA sequencing, ChIP, and rescue experiments were employed to elucidate the underlying molecular mechanism involving nerve growth factor (NGF).

Main Results:

  • RORγ is highly expressed in NSCLC and correlates with poor patient prognosis.
  • Elevated RORγ enhances NSCLC cell proliferation, migration, and invasion.
  • RORγ directly upregulates NGF transcription, promoting NSCLC progression; RORγ inhibition suppresses tumor growth and metastasis.

Conclusions:

  • RORγ is a critical driver of NSCLC progression.
  • Targeting RORγ represents a promising therapeutic strategy for NSCLC treatment.
Keywords:
AntagonistNGFNon-small cell lung cancerRORγTherapeutic target

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