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Hearing Loss in Parkinson's Disease: A Systematic Review and Meta-Analysis
Shahryar Rajai Firouzabadi1, Ida Mohammadi1, Hossein Golsorkh1
1School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Summary
Hearing loss is common in Parkinson's disease (PD), affecting over 70% of individuals. This systematic review highlights that PD-related hearing loss involves both peripheral and central auditory pathways, suggesting it may be an early non-motor symptom.
Area of Science:
- Neurology
- Audiology
- Neuroscience
Background:
- Hearing loss is an emerging non-motor symptom of Parkinson's disease (PD).
- The prevalence, specific characteristics, and underlying mechanisms of hearing loss in people with PD (PwPD) require further investigation.
Purpose of the Study:
- To systematically review and evaluate the prevalence and characteristics of hearing loss in PwPD.
- To synthesize findings from studies using pure tone audiometry, speech audiometry, and central auditory processing tests.
Main Methods:
- A comprehensive search of PubMed, Embase, and Web of Science databases was conducted.
- Included were observational studies assessing hearing loss in PwPD via audiometric and central auditory processing tests.
- Random-effects models and meta-regression were used to analyze pooled data and examine heterogeneity.
Main Results:
- The pooled prevalence of hearing loss in 1009 PwPD was 73.9%, significantly higher than in controls (OR=1.82).
- High-frequency hearing impairment was more prevalent (82.6%) than low-frequency loss (45.1%).
- Central auditory processing deficits were identified, including prolonged latencies in brainstem auditory-evoked potentials and late cortical potentials like N200 and P300.
Conclusions:
- Hearing loss is a frequent condition in PD, surpassing age-related changes.
- Findings suggest involvement of both peripheral and central auditory pathways in PD-related hearing loss.
- Hearing loss may serve as an early non-motor symptom and a potential indicator of cognitive vulnerability in PD.
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