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In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Therapeutic Potential and Mechanisms of Curcumin in Cardiovascular Diseases: A Comprehensive Review
Ahad Nourmohammad1, Niloofar Zonoubi2, Nima Ghavamikia3
1Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Background:
Curcumin is recognized for its therapeutic potential in cardiovascular diseases (CVDs), with effects on cardiomyocytes, vascular function, and hypertrophy.
Objective:
This review aims to evaluate curcumin's therapeutic effects, mechanisms of action, and safety in CVD management.
Methods:
A comprehensive review of existing literature was conducted, focusing on curcumin's impact on ischemia, hypoxia, myocardial hypertrophy, fibrosis, and endothelial function.
Results:
Curcumin protects cardiomyocytes, enhances vascular function, and exhibits inconsistent effects on cholesterol accumulation in macrophages.
Conclusion:
While curcumin shows promise as a complementary agent in CVD management, further research, particularly large-scale clinical trials, is essential to validate its efficacy and safety.
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