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Updated: Feb 1, 2026

Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo
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Published on: June 2, 2019

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Protein structure and coupled solvent dynamics in α-synuclein fibrils under controlled confinement.

Katie Lynn Whitcomb1, Kurt Warncke1

  • 1Department of Physics, Emory University, Atlanta, Georgia 30322.

Biophysical Journal
|January 31, 2026
PubMed
Summary

Parkinson's disease protein alpha-synuclein fibrils exhibit dynamic disorder. Confinement and temperature changes reveal protein collapse and folding, offering insights for drug development targeting these fibrils.

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