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Related Concept Videos

Quality Control01:05

Quality Control

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Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
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Drug Binding to Blood Components01:30

Drug Binding to Blood Components

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When drugs enter systemic circulation, they interact with various components of the blood, including proteins such as human serum albumin (HSA), α1-acid glycoprotein (AAG), lipoproteins, globulins, and red blood cells (RBCs).
HSA is the most abundant plasma protein and is vital in drug binding. It contains distinct drug-binding sites, with different drugs exhibiting affinity for specific sites. There are three main drug-binding domains for HSA: sites I, II, and III. These domains are...
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Components of Stress01:23

Components of Stress

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Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
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Components of Language01:24

Components of Language

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Language, whether spoken, signed, or written, consists of specific components: lexicon and grammar. The lexicon is the vocabulary of a language, comprising its words. Grammar is the set of rules used to convey meaning through the lexicon. For example, English grammar adds “-ed” to most verbs to indicate past tense. Words are formed by combining phonemes, which are the basic sound units of a language. Different languages have different sets of phonemes (e.g., “ah” vs.
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The Cell Cycle Control System01:28

The Cell Cycle Control System

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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The Cell Cycle Control System02:11

The Cell Cycle Control System

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Related Experiment Video

Updated: Feb 1, 2026

Automated Quantification and Analysis of Cell Counting Procedures Using ImageJ Plugins
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Automated Quantification and Analysis of Cell Counting Procedures Using ImageJ Plugins

Published on: November 17, 2016

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Automated cell count for blood component quality control.

Gemma Aran1,2, Silvia Torrents1,2, Margarita Blanco1

  • 1Laboratori Cel·lular - Banc de Sang i Teixits, Barcelona, Spain.

Transfusion
|January 31, 2026
PubMed
Summary

The XN-1000 Blood Bank mode offers an automated, reliable method for quantifying residual cells in blood components, improving quality control and lab efficiency compared to manual techniques.

Keywords:
blood componentshematology analyzerquality controlresidual cells

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Determination of Mammalian Cell Counts, Cell Size and Cell Health Using the Moxi Z Mini Automated Cell Counter
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Area of Science:

  • Blood banking and transfusion medicine
  • Hematology
  • Laboratory automation

Background:

  • Accurate quantification of residual leukocytes (rWBC) and red blood cells (rRBC) is critical for blood product safety.
  • Conventional manual flow cytometry for residual cell analysis is labor-intensive and prone to variability.
  • The XN-1000 Blood Bank (BB) mode presents an automated alternative for quality control (QC).

Purpose of the Study:

  • To validate the XN-1000 BB mode for automated QC of blood components.
  • To compare the performance of the XN-1000 BB mode against standard manual methods.
  • To assess the accuracy and efficiency of automated residual cell quantification.

Main Methods:

  • Validation of the XN-1000 BB mode for precision, linearity, and carry-over.
  • Detection of residual cells in red blood cell, platelet, and plasma products.
  • Comparison of BB mode results with manual flow cytometry and impedance-based analysis on over 1000 blood components.

Main Results:

  • The XN-1000 BB mode demonstrated high linearity, acceptable precision, and no analytical interference.
  • Residual red blood cell (rRBC) values were higher with BB mode but within specifications.
  • Platelet counts (PLT-F) were consistently higher with BB mode, reflecting true platelet content more accurately than impedance methods.

Conclusions:

  • The XN-1000 BB mode is a reliable and efficient automated alternative for blood component QC.
  • This automated method enhances laboratory throughput and simplifies QC workflows.
  • Accurate residual cell quantification is achieved, improving product quality and transfusion safety.