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Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems
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Porphyrin-Azocoumarins: Synthesis, Photophysical, Theoretical, and Biological Studies
Swathi S G1, Vighneshwar Ganesh Bhat1, Venkatesh Ranjan2
1Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore, India.
Chemistry, an Asian Journal
|January 31, 2026
Summary
New porphyrin-azocoumarin hybrids show promising antibacterial activity and low cytotoxicity. Hybrid 4 exhibited excellent results in antimicrobial and molecular docking studies, indicating therapeutic potential.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Photochemistry
Background:
- Porphyrin-coumarin hybrids combine porphyrin photophysics with coumarin biological activity.
- This study introduces novel porphyrin-azocoumarin hybrids.
Purpose of the Study:
- Synthesize and characterize new porphyrin-azocoumarin hybrids.
- Evaluate their photophysical, antimicrobial, and cytotoxic properties.
- Investigate their therapeutic potential through molecular docking.
Main Methods:
- Synthesis of porphyrin-azocoumarin hybrids.
- Photophysical characterization (UV-Vis, fluorescence spectroscopy).
- Antimicrobial assays, in vitro cytotoxicity tests (NIH3T3 cells), and molecular docking simulations.
Main Results:
- Successful synthesis of porphyrin-azocoumarins 4-6 with diverse porphyrin substituents.
- Hybrid 4 demonstrated potent antibacterial activity and superior molecular docking scores.
- All synthesized hybrids displayed low cytotoxicity against NIH3T3 cell lines.
Conclusions:
- Porphyrin-azocoumarins represent a promising class of multifunctional hybrid molecules.
- Hybrid 4 shows significant potential as an antibacterial therapeutic agent.
- Further investigation into these hybrids for therapeutic applications is warranted.
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