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Korean botulinum toxins.

Dirk Dressler1,2, Nayoung Kim3, Eric A Johnson4

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PubMed
Summary
This summary is machine-generated.

South Korea has become the global leader in botulinum toxin (BT) production, with 15 manufacturers offering 19 BT drugs. This expansion is driven by aesthetic demand, positioning Korea at the forefront of the diversifying BT market.

Keywords:
Aesthetic useBotulinum toxinDrugsKoreaManufacturersTherapeutic use

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Area of Science:

  • Biotechnology
  • Pharmaceuticals
  • Dermatology

Background:

  • Botulinum toxin (BT) has been used therapeutically since the late 1980s.
  • Initially dominated by European and US manufacturers, the BT market expanded significantly with the rise of aesthetic applications.
  • Numerous new manufacturers, particularly from South Korea, have entered the field.

Purpose of the Study:

  • To provide an overview of the rapidly expanding and diversifying botulinum toxin (BT) landscape in South Korea.
  • To detail the number of Korean manufacturers and BT drugs registered.
  • To highlight key products and their market status.

Main Methods:

  • Review of registered botulinum toxin (BT) drugs in South Korea.
  • Categorization of drugs by class, manufacturer, and indication (domestic/export).
  • Identification of drugs undergoing clinical studies in international markets.

Main Results:

  • South Korea has 15 manufacturers with 19 BT drugs registered, primarily for aesthetic uses.
  • Includes 2 Class 1 drugs (PrabotulinumtoxinA, LetibotulinumtoxinA) approved in Korea, USA, and Europe.
  • Features 12 Class 2 drugs (e.g., Neuronox®, Innotox®, Coretox®) for domestic and export markets, with Innotox® and Toxsta® in US clinical trials.
  • Additionally, 5 Class 3 drugs are registered for export only.
  • 5 manufacturers have 5 drug projects in advanced development phases.

Conclusions:

  • South Korea leads globally in the number of botulinum toxin (BT) manufacturers and drugs.
  • The Korean BT market is characterized by rapid expansion and diversification, particularly in aesthetic indications.
  • Korean BT products are gaining international recognition and market presence, with significant ongoing development.