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Updated: Feb 1, 2026

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The interplay between circadian rhythm components and apoptosis in health and disease

Mohammad Rafi Khezri1, Somayeh Mohammadi Panah2, Morteza Ghasemnejad-Berenji3,4,5

  • 1Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, 5715799313, Iran. Drmnkh76@gmail.com.

Human Cell
|January 31, 2026
PubMed

Insights

Circadian rhythms regulate gene expression and cellular homeostasis. This review explores the critical link between circadian rhythms and apoptosis in health and disease, identifying potential therapeutic targets.

Area of Science:

  • Human molecular biology
  • Cellular biology
  • Chronobiology

Background:

  • Circadian rhythms govern daily gene expression in humans, crucial for health.
  • Circadian components interact with intracellular pathways, influencing disease.
  • Apoptosis (programmed cell death) is vital for cellular homeostasis.

Purpose of the Study:

  • To review the interconnectedness of circadian rhythms and apoptosis.
  • To explore their roles in both health and disease.
  • To identify potential therapeutic strategies targeting this relationship.

Main Methods:

  • Literature review of scientific studies on circadian rhythms and apoptosis.
  • Analysis of molecular mechanisms linking circadian components and apoptotic factors.
  • Synthesis of evidence from various health and disease contexts.

Main Results:

  • Circadian rhythms and apoptosis exhibit bidirectional interactions.
  • Dysregulation of apoptosis is implicated in cancer, autoimmune, and neurodegenerative diseases.
  • These interactions offer insights into disease pathogenesis.

Conclusions:

  • The interplay between circadian rhythms and apoptosis is fundamental to human health.
  • Understanding these links can reveal novel therapeutic avenues.
  • Targeting circadian-apoptotic pathways may offer new treatment strategies for diseases.
Keywords:
ApoptosisCircadian rhythmsDiseaseHealth

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