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Aligning Intrinsic Capacity and Geroscience: Linking Function with Biology.

Sha Zhu1, Lihua Tao1, Chengcheng Fan1

  • 1Department of Neurology and Geriatrics, Peking University International Hospital, Beijing, China.

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Summary
This summary is machine-generated.

Healthy aging is a global priority. This review connects Intrinsic Capacity (IC), a measure of physical and mental function, with geroscience, exploring how to optimize IC for better aging outcomes.

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Area of Science:

  • Gerontology
  • Public Health
  • Biomedical Sciences

Background:

  • Global population aging necessitates a focus on healthy aging.
  • The World Health Organization (WHO) introduced Intrinsic Capacity (IC) as a composite of physical and mental capacities, shifting focus from disease to function.
  • Geroscience aims to understand aging biology and develop interventions to slow aging and prevent age-related decline.

Purpose of the Study:

  • To explore the conceptual and translational link between Intrinsic Capacity (IC) and geroscience.
  • To propose IC as a measurable indicator of global function and a potential target for geroscience interventions.
  • To discuss integrating IC into geroscience-informed frameworks for healthy aging.

Main Methods:

  • This narrative review synthesizes current literature on Intrinsic Capacity and geroscience.
  • It examines the hallmarks of aging in relation to IC domains.
  • It summarizes emerging gerotherapeutic strategies for IC optimization.

Main Results:

  • Intrinsic Capacity (IC) can serve as a measurable indicator of overall functional status in aging.
  • The hallmarks of aging are linked to declines in IC domains.
  • Gerotherapeutic approaches show potential for optimizing IC.

Conclusions:

  • Intrinsic Capacity (IC) and geroscience are conceptually and translationally connected.
  • IC optimization is a promising strategy for healthy aging.
  • Integrating IC into public health frameworks can guide personalized preventive strategies.