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Four New Polyhydroxylated Secondary Metabolites From Sinularia sp. and Their Biological Activities
Cheng-Hao Jin1,2, Jiafu Cao3, Li-Ting Zhang2
1Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
None:
The chemical investigation on the diethyl ether extract of soft coral Sinularia sp. collected from the South China Sea has led to the isolation and characterization of two new steroids (1 and 2) and two new α-tocopherylquinones (3 and 4), along with four known related analogs (5-8). The structure of new compounds 1-4 was determined by the combination of extensive spectroscopic data analyses, chemical conversion, and comparison of the spectral data with those of corresponding reported compounds in the literature. In bioassays, compound 6 displayed moderate cytotoxic effects against MV-4-11, MDA-MB-231, and HT-29 cells with IC50 values of 19.47 ± 0.33, 15.5 ± 0.46, and 12.26 ± 0.19 µM, respectively. In addition, compound 1 exhibits cytotoxic effects against Hep3B cells with IC50 values of 26.45 ± 0.92 µM and compound 3 shows cytotoxicity against MV-4-11 cells with IC50 values of 37.63 ± 0.53 µM.
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