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Four New Triterpenoids From Rubus pirifolius Smith.
Xiao-Yan Ning1,2, Mei-Fang Huang1,2, Wen-Jiao Chen1,2
1Guangxi University of Chinese Medicine, Nanning, P. R. China.
Chemistry & Biodiversity
|January 31, 2026
Summary
Four new triterpenoids were isolated from Rubus pirifolius Smith. Compounds 10 and 11 showed significant cytotoxicity against leukemia, lung, liver, breast, and colon cancer cell lines.
Area of Science:
- Natural Product Chemistry
- Medicinal Chemistry
- Pharmacology
Background:
- Rubus species are a rich source of bioactive natural products.
- Triterpenoids are a class of compounds with diverse biological activities, including anticancer properties.
Purpose of the Study:
- To isolate and characterize new triterpenoids from Rubus pirifolius Smith.
- To evaluate the cytotoxic potential of isolated triterpenoids against various human cancer cell lines.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation of new compounds by spectroscopic methods (NMR, MS).
- Cytotoxicity assays using HL-60, A549, SMMC-7721, MDA-MB-231, and SW480 cell lines.
Main Results:
- Four new triterpenoids, pirifoliusic acids B-E, were identified.
- Seven known triterpenoids were also isolated.
- Compounds 10 and 11 demonstrated significant cytotoxicity against all tested cancer cell lines.
Conclusions:
- Rubus pirifolius Smith is a valuable source of cytotoxic triterpenoids.
- Compounds 10 and 11 hold potential as lead compounds for anticancer drug development.
