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Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation
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Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation

Published on: January 10, 2025

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Curcumin nanoparticles attenuate sepsis-induced myocardial injury by modulating the Nrf2/HO-1/SLC7A11/GPX4 and

Yuhang Wang1, Han Zhang1, Jiaqi Liu1

  • 1College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China.

Pathology, Research and Practice
|January 31, 2026
PubMed
Abstract

Insights

Curcumin nanoparticles effectively treat sepsis-induced myocardial injury by inhibiting ferroptosis. This novel nanodelivery system improves curcumin

Area of Science:

  • Cardiovascular Research
  • Nanomedicine
  • Molecular Biology

Background:

  • Sepsis-induced myocardial injury (SIMI) is a life-threatening condition.
  • Curcumin (Cur) shows therapeutic potential for SIMI but suffers from low bioavailability.
  • Nanodelivery systems offer a strategy to enhance curcumin's efficacy.

Purpose of the Study:

  • To investigate the therapeutic effects of curcumin nanoparticles (Cur-NPs) on SIMI.
  • To elucidate the molecular mechanisms underlying Cur-NPs' action in septic myocarditis.

Main Methods:

  • Cur-NPs were prepared using ion cross-linking.
  • A mouse model of septicemia was induced by lipopolysaccharide (LPS).
  • Molecular biology techniques including immunofluorescence, Western blot, and RT-qPCR were used.

Main Results:

  • Cur-NPs significantly reduced myocardial damage, inflammation, and mitochondrial injury in septic mice.
  • Cur-NPs modulated key proteins involved in ferroptosis, including upregulation of Nrf2, HO-1, SLC7A11, GPX4, FSP1, and ferritin.
  • Cur-NPs downregulated ferroptosis markers ACSL4, LPCAT3, and 4-HNE.

Conclusions:

  • Cur-NPs effectively alleviate SIMI by inhibiting ferroptosis in cardiomyocytes.
  • Therapeutic effects are mediated by dual regulation of the Nrf2/HO-1/xCT/GPX4 and ACSL4/LPCAT3 pathways.
  • Cur-NPs represent a promising therapeutic strategy for clinical treatment of SIMI.
Keywords:
Curcumin nanoparticlesFerroptosisInflammationOxidative stressSepsis-induced myocardial injury

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