Near infrared mediated organic electrochemical transistor biosensor with rolling circle amplification for signal amplified detection of okadaic acid
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Updated: Feb 2, 2026

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
Published on: February 10, 2014
Tiantong Jiang1, Peng Ju2, Yueyue Su3
1Qingdao Key Laboratory of Analytical Technology Development and Offshore Eco-Environment Conservation, Marine Bioresource and Environment Research Center, First Institute of Oceanography, Ministry of Natural Resources, No. 6 Xianxialing Road, Qingdao 266061, PR China; College of Marine Life Sciences, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, PR China.
Abstract:
Light-driven organic electrochemical transistors (OECTs) have demonstrated promise in the realm of biological analysis. Drawing inspiration from photoelectrochemical techniques within the near-infrared (NIR), a NIR-responsive OECT biosensor was proposed to detect okadaic acid (OA). Upon NIR irradiation, the plasmonic effect of MXene amplifies the NIR sensitivity of CuInS2, and it enhances the photoelectrochemical (PEC) properties under NIR excitation. This conversely elevated photoelectric conversion efficiency, facilitated efficient carrier transport under NIR stimulation, modulated the doping state of the channel, and promoted the operation of the OECTs. At the CuInS2/MXene electrolyte, the target-dependent modulation of the channel current was tuned through the integration of rolling circle amplification and biocatalytic precipitation processes, culminating in the successful construction of a precise OA detection system. Experimental findings indicated that the developed sensing strategy exhibited linear response across a concentration range of 0.1 nM-1 μM, with a detection limit as low as 38.6 pM.
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