Related Experiment Video

Updated: Feb 2, 2026

Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals
04:28

Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals

Published on: March 23, 2016

13.2K

The utilization of oral feeding in pediatric pancreatitis: a randomized controlled study

Yan Han1, Hong Zhao1, Linchen Fu1

  • 1Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China.

Jornal De Pediatria
|January 31, 2026
PubMed

Insights

Early oral feeding is effective for pediatric acute pancreatitis (AP), showing similar pain duration and weight changes compared to nasogastric (NG) feeding. Oral feeding may reduce complications in children with mild to moderate AP.

Area of Science:

  • Pediatric Gastroenterology
  • Nutritional Therapy
  • Acute Pancreatitis Research

Background:

  • Early nutritional intervention is crucial for children with acute pancreatitis (AP).
  • Comparing oral feeding versus nasogastric (NG) feeding is essential for optimizing AP management in pediatric patients.

Purpose of the Study:

  • To compare the efficacy and safety of oral feeding versus NG feeding in children with mild to moderately severe AP.
  • To evaluate outcomes including pain duration, nutritional tolerance, and weight changes.

Main Methods:

  • A prospective, randomized controlled trial involving 48 pediatric patients with mild to moderate AP.
  • Participants were randomized into oral feeding or NG feeding groups.
  • Primary outcomes assessed were AP-related pain duration, tolerance rate, and weight changes.

Main Results:

  • No significant differences were observed in pain duration (3 days median for both groups) or tolerance rates between oral and NG feeding groups.
  • Weight changes were comparable between groups at discharge and follow-up points (1 and 5 weeks post-discharge).
  • Fewer complications were noted in the oral feeding group (0) compared to the NG group (4), though this difference was not statistically significant (p=0.109).

Conclusions:

  • Oral feeding is a safe and effective nutritional strategy for children with mild to moderate AP.
  • This approach can potentially reduce the need for invasive procedures like NG tube placement.
  • Oral feeding demonstrates comparable efficacy to NG feeding regarding pain and weight, with a trend towards fewer complications.
Abstract

Keywords:
Acute pancreatitisEnteral nutritionNutritional therapyOral feedingPediatrics

More Related Videos

A Bacterial Oral Feeding Assay with Antibiotic-Treated Mosquitoes09:59

A Bacterial Oral Feeding Assay with Antibiotic-Treated Mosquitoes

Published on: September 12, 2020

7.1K
Experimental Viral Infection in Adult Mosquitoes by Oral Feeding and Microinjection08:02

Experimental Viral Infection in Adult Mosquitoes by Oral Feeding and Microinjection

Published on: July 28, 2022

3.0K

Related Concept Videos

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
252
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
472
Random Error01:04

Random Error

Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.8K
Random Variables01:09

Random Variables

A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
17.8K
Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
9.1K
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
14.9K