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In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
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Generation and functional evaluation of STAb-T cells

Anaïs Jiménez-Reinoso1, Belén Blanco1, Luis Álvarez-Vallina1

  • 1Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

Methods in Cell Biology
|January 31, 2026
PubMed

STAb-T therapy is an emerging cancer immunotherapy strategy that combines the advantages of adoptive cell therapies and bispecific antibodies. STAb (Secreting T cell engager bispecific Antibodies) T cells are T lymphocytes genetically engineered to secrete bispecific T cell engagers (TCEs) that recruit T cells to target and destroy tumor cells. Adoptive transfer of STAb-T cells has demonstrated potent anti-tumor activity in preclinical models and evaluation in human patients is forthcoming. Here, we provide comprehensive guidelines for generating STAb-T cells and assessing their functionality and efficacy in vitro and in relevant in vivo models of hematological malignancies.

Keywords:
Cancer immunotherapy, adoptive T cell therapy, bispecific antibodies, T cell engagers, STAb-T cells

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