Related Experiment Video
Updated: Jul 8, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
Dynamic brain synergy uncovers functional neural coordination in Parkinson's disease under dopaminergic modulation
Jiewei Lu1,2,3, Yuanyuan Cheng4, Xinyuan Zhang1
1College of Artificial Intelligence, Nankai University, Tianjin, 300350, People's Republic of China.
Background:
Brain synergy and redundancy are emerging as pivotal aspects to understand neural functions, providing insights into high-order information that traditional functional connectivity (FC) methods cannot access. Despite their significance, these aspects have not been investigated in Parkinson's disease (PD). This paper advances the understanding of synergy and redundancy by integrating them with dynamic analysis, which is essential in the investigation of PD.
Methods:
Dynamic brain synergy and redundancy were developed and quantified by the constructed dynamic information decomposition framework, and was applied to walking-state functional near-infrared spectroscopy (fNIRS) signals of 63 PD patients undergoing dopaminergic treatment and 36 healthy controls.
Results:
Dynamic brain synergy was restored to normal levels following dopaminergic treatment. Dynamic FC could not access high-order neural information and had insignificant variations in dopaminergic modulation among PD patients, and dynamic brain redundancy also exhibited insignificant treatment-induced variations.
Conclusion:
Dynamic brain synergy offers an advancing perspective on neural dynamics and promises to uncover high-order functional biomarkers for PD early diagnosis and individualized treatment.
Trial Registration:
This study has been registered in Chinese Clinical Trial Registry (ChiCTR1900022655).
Related Concept Videos
Neural Regulation
Brainstem
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
Parkinson's Disease: Overview
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction
Parkinson Disease ll: Pathophysiology

