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Study on the evaluation of left atrial structure and function in patients with H-type hypertension using 4D automated

Xu Huang1, Xiaolin Wang1, Shuangyi Cao1

  • 1Department of Ultrasound, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1, Minde Road, Donghu District, Nanchang, Jiangxi, 330006, People's Republic of China.

BMC Cardiovascular Disorders
|January 31, 2026
PubMed

Insights

H-type hypertension is linked to reduced left atrial function, with higher homocysteine levels worsening this strain. These findings suggest left atrial strain parameters may indicate early myocardial injury in these patients.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Biomarker Discovery

Background:

  • H-type hypertension presents unique challenges in cardiovascular health.
  • Assessing left atrial structure and function is crucial for understanding hypertensive heart disease.
  • The role of serum homocysteine (Hcy) in left atrial dysfunction requires further investigation.

Purpose of the Study:

  • To evaluate left atrial structure and function in patients with H-type hypertension using 4D Auto LAQ.
  • To determine the impact of serum homocysteine levels on the left atrium in primary hypertension.
  • To identify potential early indicators of left atrial myocardial injury.

Main Methods:

  • Utilized four-dimensional automated left atrial quantitative analysis (4D Auto LAQ) technology.
  • Enrolled 173 newly diagnosed primary hypertension patients (85 H-type, 88 non-H-type) and 60 healthy controls.
  • Analyzed serum homocysteine, lipid profiles, eGFR, uric acid, and left atrial strain parameters (LASr, LASct, LASr-c, LASct-c).

Main Results:

  • H-type hypertension group showed significant differences in Hcy, cholesterol, triglycerides, eGFR, and uric acid compared to controls.
  • Patients with H-type hypertension exhibited decreased left atrial strain parameters (LASr, LASct, LASr-c, LASct-c).
  • Elevated plasma Hcy levels were independently associated with reduced left atrial strain parameters.

Conclusions:

  • H-type hypertension is associated with impaired left atrial strain.
  • Increasing serum Hcy levels correlate with worsening left atrial strain dysfunction.
  • Left atrial strain parameters may serve as early biomarkers for myocardial injury in H-type hypertension.
Abstract

Keywords:
4D auto LAQEchocardiographyH-type hypertensionHomocysteineLeft atrial strain

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