Related Experiment Video
Updated: Feb 3, 2026
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Abnormal dynamic functional connectivity in different gray matter volume subtypes of patients with major psychiatric
Shancong Li1, Weiqi Qin1, Siyi Wei2
1Department of Psychiatry, Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China; Heilongjiang Provincial Key Laboratory of Precise Diagnosis and Neuropsychological Regulation of Mental Disorders, Heilongjiang, 161006, China.
Background:
Major psychiatric disorders (MPDs), including schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and obsessive-compulsive disorder (OCD), have been classified as distinct diagnostic categories based on clinical symptoms. However, neuroimaging studies suggest that these MPDs share similar brain structure and functional characteristics. The present study aim to explore potential subtypes of MPDs based on gray matter volume (GMV) in a trans-diagnostic sample.
Methods:
We involved 84 patients with MPDs (22 SZ, 22 BD, 18 MDD, 22 OCD) and 39 healthy controls (HCs). Voxel-based morphometry (VBM) and dynamic functional connectivity (dFC) analyses were used to investigate the GMV and the dynamic characteristics of the whole brain at rest. The heterogeneity through discriminant analysis (HYDRA) approach was applied to identify the subtypes of MPDs.
Results:
Two distinct subtypes were identified, subtype-I (S-I) showed increased GMVs in subcortical brain regions, while subtype-II (S-II) displayed decreased GMVs in cerebral cortex regions. Both S-I and S-II patients showed reduced dFC values within the connected edges at rest. The negative correlation between total GMVs and disease duration were observed in S-II patients.
Conclusions:
The present results may contribute to understand the pathogenesis and biological classification of MPDs.
Related Concept Videos
01:27Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
01:17Functions of Connective Tissues
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
02:49Classifying Matter by State
02:23Abnormal Proliferation
03:35Classifying Matter by Composition
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
02:57Physical and Chemical Properties of Matter