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Updated: Feb 3, 2026

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
Published on: January 7, 2013
Mitochondrial changes in clear cell renal cell carcinoma: mechanisms and potential targets
Jiayi Yang1, Xiaoyan Pan2, Xiaoyan Luo3
1Department of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
None:
Renal cell carcinoma (RCC), the most common type of urogenital cancer, accounts for about 80 % of malignant renal tumors. Clear cell renal cell carcinoma (ccRCC), composed of cells filled with lipid droplets in cytoplasm, is the most common subtype of RCC. Mechanisms underlying ccRCC progression and metastasis are complicated and remain far from being clarified. Mitochondria, which serve as cellular energy supplier and central signal hubs, are involved in various physiological and pathological processes. Mounting evidence has revealed that mitochondrial changes, such as mutations, abnormal mitophagy and metabolisms and excessive reactive oxide species (ROS) are closely related with the progression, prognosis, metastasis and drug resistance of RCC and ccRCC. In this review, we'll provide an overview on mitochondrial changes in RCC, especially in ccRCC, and discuss their possible roles in the tumorigenesis and prognosis as well as their potential in serving as biomarkers and therapeutic targets.
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