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A Murine Model of Subarachnoid Hemorrhage
Published on: November 21, 2013
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Why Do Patients With Aneurysmal Subarachnoid Hemorrhage Postpone Treatment?
Ksenia Yarova1, Yuliia Solodovnikova1
1Department of Neurology and Neurosurgery, Odesa National Medical University, Odesa, Ukraine.
World Neurosurgery
|February 1, 2026
Summary
Delayed diagnosis of cerebral arterial aneurysm (CAA) rupture, especially in recurrent cases, is linked to non-focal symptoms and social barriers. Prompt medical evaluation by specialists significantly reduces diagnostic delays.
Area of Science:
- Neurology
- Neurosurgery
- Public Health
Background:
- Early diagnosis of cerebral arterial aneurysm (CAA) rupture is critical for improving patient prognosis and reducing mortality.
- Recurrent ruptures significantly worsen outcomes, yet diagnosis timing varies widely based on symptom presentation.
- Understanding factors influencing help-seeking behavior is crucial for timely CAA rupture diagnosis.
Purpose of the Study:
- To identify predictors of help-seeking behavior in patients experiencing recurrent cerebral arterial aneurysm ruptures.
- To analyze factors contributing to diagnostic delays in cerebral arterial aneurysm rupture cases.
Main Methods:
- Retrospective analysis of 448 patients with ruptured cerebral arterial aneurysm (CAA) from 2000-2023.
- Patients categorized into single vs. recurrent rupture groups; pre-hospital period defined as time from first rupture to diagnosis.
- Evaluation of sociodemographics, CAA characteristics, neurological symptoms, and physician specialty's impact on diagnosis timeliness.
Main Results:
- Significant diagnostic delays observed in recurrent CAA rupture patients, with verification occurring 5-6 days later than in single rupture cases.
- Recurrent thunderclap headaches paradoxically prolonged diagnosis, while severe symptoms (paresis, seizures, LOC) accelerated it by 12-23 days.
- Neurologist/neurosurgeon evaluation reduced delays by ~7 days; misdiagnosis by non-specialists caused ~10-day delays.
Conclusions:
- Non-focal symptoms, female gender, and social-psychological barriers are key predictors of delayed consultation for CAA rupture.
- Improving early diagnosis and enhancing patient awareness of CAA risks are essential public health goals.
- Specialist evaluation is vital for reducing diagnostic delays in cerebral arterial aneurysm rupture.
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