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The Thyroid Gland01:23

The Thyroid Gland

7.7K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.7K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.6K
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

1.8K
A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
1.8K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.8K
Primary Active Transport01:47

Primary Active Transport

198.5K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
198.5K
Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

60.5K
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.5K

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Related Experiment Video

Updated: Feb 3, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

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Radiofrequency Ablation for Primary Thyroid Cancer.

Iram Hussain1

  • 1Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|February 1, 2026
PubMed
Summary
This summary is machine-generated.

Radiofrequency ablation (RFA) offers a minimally invasive option for low-risk papillary thyroid cancer. This treatment shows significant tumor reduction, low recurrence, and preserves thyroid function, making it a viable alternative to surgery.

Keywords:
low risk thyroid cancerpapillary thyroid carcinomapapillary thyroid microcarcinomaradiofrequency ablationthermal ablationthyroid cancer

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Area of Science:

  • Oncology
  • Minimally Invasive Surgery

Background:

  • Papillary thyroid carcinoma (PTC), especially papillary thyroid microcarcinomas (PTMC), is increasingly managed with minimally invasive techniques.
  • Radiofrequency ablation (RFA) presents a promising alternative to traditional treatments for selected PTC cases.

Purpose of the Study:

  • To review the current evidence on the indications, efficacy, and safety of RFA for managing low-risk PTC.
  • To evaluate RFA as a treatment option compared to surgery and active surveillance.

Main Methods:

  • Systematic review of recent studies on RFA for PTC.
  • Analysis of data regarding tumor response, progression, recurrence rates, and safety profile.
  • Evaluation of RFA's impact on thyroid function and patient recovery.

Main Results:

  • RFA demonstrates significant tumor volume reduction with high rates of complete or near-complete response.
  • Low progression and recurrence rates were observed, alongside a favorable safety profile.
  • Advantages include preserved thyroid function, no visible scarring, and shorter recovery times.

Conclusions:

  • RFA is recognized in emerging guidelines as a viable option for carefully selected low-risk PTC, especially tumors <1 cm without extrathyroidal extension or nodal involvement.
  • Current data support RFA as an effective, safe, and well-tolerated alternative to surgery and active surveillance.
  • Further long-term data are needed to confirm durability, and development of specialized centers is crucial due to operator dependency.