Related Experiment Video
Updated: Feb 3, 2026
08:03
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
9.5K
Cutaneous Toxicities of Small Molecules in Targeted Cancer Therapy Part II - Approach to Management and Treatment
Ian Nykaza1, Bernice Kwong2, Allison Gordon1
1Memorial Sloan Kettering Cancer Center, Department of Medicine, Dermatology Service, New York, NY, USA; Weill Cornell Medicine, New York, NY USA.
Journal of the American Academy of Dermatology
|February 1, 2026
Abstract:
With the rapid expansion of small molecule inhibitors (SMIs) in oncology, the incidence and complexity of dermatologic adverse events (dAEs) have significantly risen1. While SMIs target essential oncogenic pathways, they frequently result in dermatologic toxicities that can impact patient quality of life and lead to dose reduction, treatment interruption, or discontinuation of life-prolonging therapy1. Effective management of these toxicities is critical not only for preserving skin integrity but also for ensuring ongoing oncologic treatment. Part II of this CME discusses guidance on oncodermatologic management for dermatologic toxicities due to SMIs.
Keywords:
AKTAcneiform dermatitisAcneiform eruptionActinic keratosesBRAFBurton’s tyrosine kinase (BTK)CDK4/6CSF1REGFR (epidermal growth factor receptor)ERKEZH2FGFRFLT3HH (Hedgehog) pathwayJAK inhibitorsJAK/STAT pathwayKITMAPK/ERK pathwayMEKMETNotch signalingPARPPDGFRPI3KPI3K/AKT/mTOR pathwayRASRAS/MAPK pathwayRETSMO inhibitionSRC kinase familyStevens-Johnson syndrome (SJS)TRKVEGFRXPO1alopeciaaphthous ulcersatypical nevib-cell lymphoma-2 (BCL-2)basal cell carcinoma (BCC)breakpoint cluster region-Abelson murine leukemia (BCR-ABL)bullous pemphigoid (BP)cheilitiscutaneous epithelial proliferations (CEP)drug-induced hypersensitivity syndrome (DIHS/DRESS)eczematous dermatitisepidermal hyperplasiaepidermal necrolysis (TEN)epidermoid cystsepigenetic inhibitorsepigenetic regulationeruptive nevifolliculocentric eruptionshair changeshair depigmentationhand-foot skin reaction (HFSR)hirsutismhistone deacetylase (HDAC)hyperkeratosishyperpigmentationhypopigmentationhypoxia inducible factor (HIF)ichthyosiform eruptioninterface dermatitisisocitrate dehydrogenase (IDH1/2)keratoacanthomaskeratosis pilaris-like eruptionslichenoid eruptionmTORmaculopapular rashmelanocytic lesionsmelanomamelanonychiamucositismultikinase inhibitorsnail brittlenessnail dystrophynail pigment changesnon-kinase inhibitorsnon-receptor tyrosine kinase inhibitors (NRTKIs)oral lichenoid lesionspalmoplantar erythrodysesthesia (PPE)palmoplantar keratoderma (PPK)papulopustularparonychiaphotosensitivitypigmentary changesproteasomepsoriasiform eruptionreceptor tyrosine kinase inhibitors (RTKIs)sebaceous gland dysfunctionseborrheic keratosesserine/threonine kinase inhibitorssmall molecule inhibitors (SMIs)spongiotic dermatitissquamous cell carcinoma (SCC)stomatitistrichomegalytyrosinase inhibitionvitiligoxerosisxerostomiay-secretase
Related Concept Videos
02:57Targeted Cancer Therapies
8.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.9K
02:49Cancer Therapies
10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
02:56Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
00:59Gene Therapy
27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
01:16Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
619
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
619
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
742
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
742