Related Experiment Video

Updated: Feb 3, 2026

Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface
07:04

Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface

Published on: July 21, 2016

21.6K

Placental Growth Factor and Fetal Macrosomia: A Retrospective Cohort Study in a Western Canadian Tertiary Centre

Ernesto Figueiro-Filho1, Sumayya Imran1, Adrielle Souza Lira1

  • 1Department of Obstetrics and Gynaecology, University of Saskatchewan, Regina, SK.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|February 1, 2026
PubMed

We studied a retrospective cohort of 377 pregnancies at a Canadian tertiary centre to explore whether low maternal placental growth factor (PlGF) is linked to suspected fetal macrosomia (estimated fetal weight ≥90th percentile by ultrasound), macrosomic neonates (>4000 g), and adverse perinatal outcomes. Low PlGF pregnancies showed elevated BMI, hypertension, and preeclampsia and were associated with earlier delivery, preterm birth, neonatal intensive care unit admission, and placental vascular malperfusion. Macrosomic birthweight was not associated with PlGF status. Although suspected macrosomia by ultrasound appeared more frequently in patients with low PlGF, this association requires further investigation.

Keywords:
Placental growth factorcohortmacrosomiaplacental dysfunctionretrospective

More Related Videos

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo06:43

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo

Published on: November 8, 2018

11.0K
Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

28.7K

Related Concept Videos

Tertiary Healthcare System01:21

Tertiary Healthcare System

Specialized care provided over an extended period is called tertiary care. Usually, a primary or secondary care physician will refer a patient to tertiary care. A patient's maximum physical and mental function is restored in tertiary care, which is caused due to the impact of a chronic illness or condition. Tertiary care aims to achieve the highest level of functioning possible while managing chronic illness. For example, a patient who falls and fractures their hip will need secondary care...
2.2K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
3.9K
Factors Influencing Microbial Growth: pH01:29

Factors Influencing Microbial Growth: pH

Microorganisms are classified as acidophiles, neutrophiles, or alkaliphiles based on their pH growth preferences, reflecting their adaptations to specific environments. Maintaining a stable intracellular pH is critical for macromolecular stability and enzymatic activity, which can be challenged by external pH variations.Neutrophiles, such as Escherichia coli, grow optimally between pH 5.5 and 8.0. These microorganisms inhabit neutral or slightly acidic environments and employ mechanisms like...
1.2K
Factors Influencing Microbial Growth: Temperature01:27

Factors Influencing Microbial Growth: Temperature

Microorganisms display remarkable adaptations, enabling them to thrive in diverse ecological niches across a wide range of temperatures. Temperature profoundly influences microbial growth by affecting enzymatic activity, membrane fluidity, and other cellular processes.Each microorganism operates within a specific temperature range defined by three cardinal points: minimum, optimum, and maximum. Below the minimum temperature, membranes lose fluidity, halting transport processes. Above the...
1.3K
Factors Influencing Microbial Growth: Osmolarity01:28

Factors Influencing Microbial Growth: Osmolarity

Osmolarity is the measure of solute concentration in a solution. It plays a critical role in determining water availability for organisms. Water moves across semipermeable membranes through osmosis, flowing from regions of lower solute concentration (more dilute) to regions of higher solute concentration (more concentrated).In high-solute environments, microbial cells lose water, leading to dehydration and inhibited growth. The extent to which water is available to microbes in such environments...
874
Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
3.1K