Transcatheter Mitral Edge-to-edge Repair in Patients with Transthyretin Cardiac Amyloidosis: A Four-case Series

Area of Science:

• Cardiology
• Cardiovascular Medicine
• Medical Devices

Background:

• Cardiac amyloidosis involves amyloid fibril deposition, leading to complications like mitral regurgitation (MR).
• The effectiveness of transcatheter mitral edge-to-edge repair (TEER) for MR in amyloidosis patients is not well-established.

Purpose of the Study:

• To evaluate the efficacy and outcomes of TEER in patients with transthyretin cardiac amyloidosis.

Main Methods:

• Case series presentation of four patients undergoing TEER for transthyretin cardiac amyloidosis.
• Assessment of MR reduction post-TEER and evaluation of short-term and long-term clinical outcomes.

Main Results:

• TEER successfully reduced MR in all four patients.
• Two patients died within one year post-procedure.
• One patient experienced recurrent MR deterioration.

Conclusions:

• TEER can effectively mitigate MR in cardiac amyloidosis.
• Poor long-term outcomes are associated with disease progression and comorbidities.
• Careful patient selection is crucial for TEER in cardiac amyloidosis.