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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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Multi-omics integration in deciphering non-small cell lung cancer drug resistance: current status, challenges, and

Jidong Miao1, Wenqiang Guan1, Jing Wang1

  • 1Department of Oncology, Zigong Fourth People's Hospital, Zigong, Sichuan Province, 643000, China.

Hereditas
|February 1, 2026
PubMed

Insights

This review highlights how multi-omics integration reveals non-small cell lung cancer (NSCLC) drug resistance mechanisms. It identifies biomarkers and therapeutic targets to overcome resistance and improve patient outcomes.

Area of Science:

  • Oncology and Molecular Biology
  • Genomics and Bioinformatics

Background:

  • Lung cancer is the leading cause of cancer mortality worldwide.
  • Non-small cell lung cancer (NSCLC) represents 85% of lung cancer cases.
  • Drug resistance significantly limits the effectiveness of NSCLC treatments.

Purpose of the Study:

  • To review recent advancements in understanding NSCLC drug resistance through multi-omics integration.
  • To highlight the role of multi-omics in identifying resistance mechanisms, biomarkers, and therapeutic targets.
  • To discuss strategies for overcoming drug resistance in NSCLC.

Main Methods:

  • Systematic review of literature on multi-omics approaches in NSCLC research.
  • Integration of diverse omics data (genomics, transcriptomics, proteomics, etc.) to analyze drug resistance.
  • Identification of molecular networks and key players involved in treatment failure.

Main Results:

  • Multi-omics integration provides a comprehensive view of NSCLC drug resistance pathways.
  • Key biomarkers and drug targets for overcoming resistance have been identified.
  • Small-molecule inhibitors and combination therapies show promise in reversing resistance.

Conclusions:

  • Multi-omics integration is crucial for dissecting complex NSCLC drug resistance mechanisms.
  • Targeted therapies and combination strategies guided by multi-omics data can enhance treatment efficacy.
  • Future research should focus on advanced multi-omics technologies, AI-driven analysis, and personalized medicine for improved NSCLC patient prognosis.
Keywords:
Drug resistance mechanismGenomicsMulti-omics integrationNon-small cell lung cancerProteomicsSingle-cell analysis

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