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Updated: Feb 3, 2026

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Pediatric intramedullary spinal tumors: Pathological and clinical outcomes in a 96-case single-institution cohort

Yiji Li1, Mingquan Liu1, Dongao Zhang1

  • 1Department of Neurosurgery, Department of Spine, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|February 1, 2026
PubMed

Insights

Pediatric spinal cord tumors impact child development. High Ki-67 and p53 expression correlate with poorer survival, while tumor length affects short-term function, not long-term outcomes.

Area of Science:

  • Pediatric Oncology
  • Neurosurgery
  • Cancer Pathology

Background:

  • Pediatric intramedullary spinal cord tumors (PIMSCTs) pose significant risks to children's development.
  • Understanding pathological features and prognostic factors is crucial for improving outcomes.

Purpose of the Study:

  • To evaluate the pathological characteristics of PIMSCTs.
  • To analyze factors influencing clinical outcomes and neurological function in pediatric patients.

Main Methods:

  • Retrospective analysis of 96 children with PIMSCTs treated surgically (January 2015 - June 2024).
  • Comprehensive analysis of clinical and pathological data.
  • Exploration of prognostic and neurological function-related factors.

Main Results:

  • Astrocytoma was the most common pathology; thoracic spine tumors were most frequent.
  • Tumor WHO grade, Ki-67, and p53 expression significantly impacted survival.
  • Short-term neurological function correlated with tumor length and initial status; long-term function was influenced by age, WHO grade, syringomyelia, postoperative status, and PLR changes.

Conclusions:

  • High Ki-67 and p53 expression are linked to poorer prognosis in PIMSCTs.
  • Tumor length affects short-term neurological function, but not long-term outcomes.
  • Long-term neurological function depends on tumor characteristics and postoperative status, with PLR changes as a potential indicator.
Abstract

Keywords:
AstrocytomaIntramedullary spinal tumorsNeurological functionPediatricSurgical outcomes

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