Pulmonary Safety and Clinical Considerations for Inhaled Insulin: A Comprehensive Review
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View abstract on PubMed
Summary
This summary is machine-generated.Technosphere® Insulin (TI) is the only rapid-acting inhaled insulin available. Evidence suggests TI is safe for type 1 and type 2 diabetes patients, with only mild, transient cough as a common side effect.
Area Of Science
- Pulmonary medicine
- Endocrinology
- Pharmacology
Background
- Exubera®, the first inhaled insulin, was FDA-approved in 2006 but withdrawn in 2007.
- Technosphere® Insulin (TI) is the sole rapid-acting inhaled insulin currently available, approved by the FDA.
Purpose Of The Study
- To address pulmonary safety concerns associated with Technosphere® Insulin (TI).
- To present evidence on the safety of TI in patients with type 1 and type 2 diabetes.
Main Methods
- Review of recent studies on TI efficacy and adverse events.
- Analysis of safety data from clinical trials in diabetic populations.
Main Results
- TI has demonstrated efficacy with no significant adverse events beyond mild, transient cough.
- The mild cough associated with TI typically diminishes over time.
Conclusions
- TI is a safe and effective rapid-acting inhaled insulin for managing type 1 and type 2 diabetes.
- Evidence supports the pulmonary safety of TI, even with chronic use.
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