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Related Experiment Video

Updated: Feb 3, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
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X-Ray Repair Cross-Complementing Group 1 Genetic Polymorphisms and the Risk of Sudden Sensorineural Hearing Loss.

Shu-Yu Tai1,2, Ning-Chia Chang3,4, Su-Hui Hsiao5

  • 1Department of Family Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
|February 2, 2026
PubMed
Summary
This summary is machine-generated.

The TT genotype of the XRCC1 gene (rs1799782) is linked to a higher risk of sudden sensorineural hearing loss (SSNHL). This genetic association was found in the Taiwanese population, suggesting a potential role for DNA repair genes in SSNHL development.

Keywords:
Genetic polymorphismSudden sensorineural hearing lossX-ray repair cross-complementing group 1

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Area of Science:

  • Genetics
  • Otolaryngology
  • Molecular Biology

Background:

  • Sudden sensorineural hearing loss (SSNHL) etiology is often unknown, with potential vascular and genetic factors.
  • The X-ray repair cross-complementing group 1 (XRCC1) gene, crucial for DNA repair and oxidative stress, has been implicated in other vascular and hearing-related conditions.

Purpose of the Study:

  • To investigate the association between specific single nucleotide polymorphisms (SNPs) in the XRCC1 gene and the risk of developing SSNHL.
  • To explore the role of XRCC1 gene variations in SSNHL susceptibility within the Taiwanese population.

Main Methods:

  • A prospective case-control study was conducted with 276 SSNHL patients and 293 healthy controls.
  • Three XRCC1 SNPs (rs1799782, rs25489, rs25487) were genotyped using TaqMan assays.
  • Multivariate logistic regression analyzed associations under dominant and recessive models, controlling for potential confounders.

Main Results:

  • The TT genotype of XRCC1 rs1799782 showed a significant association with increased SSNHL risk (aOR=2.005, P=0.0164), consistent under recessive models.
  • No significant associations were found for XRCC1 SNPs rs25489 and rs25487.
  • High-tone and flat-type audiogram patterns, along with delayed treatment, correlated with poorer clinical outcomes, but XRCC1 genotypes did not predict treatment response.

Conclusions:

  • The TT genotype of XRCC1 rs1799782 is a significant risk factor for SSNHL susceptibility in the Taiwanese population.
  • This finding highlights the potential involvement of DNA repair gene polymorphisms in the pathogenesis of SSNHL.