Targeting the Perialar Space for Enhanced Nasolabial Fold Rejuvenation: A Cadaveric Study

Area of Science:

• Anatomy
• Facial Aesthetics
• Injectable Treatments

Background:

• Nasolabial folds result from complex anatomical interactions and muscle tension.
• The deep pyriform space is a common injection site for these folds, but filler migration is a concern.

Purpose of the Study:

• To investigate the perialar space as a novel anatomical target for nasolabial fold volumization.
• To assess the potential for more effective and stable filler placement in this distinct medial space.

Main Methods:

• Dissection and injectate distribution analysis in 22 fresh cadavers (44 hemifaces).
• Measurement of cannula resistance during injection into deep pyriform and perialar spaces.
• Histological evaluation to confirm anatomical boundaries.

Main Results:

• Injectate was successfully placed in the perialar space, distinct from the deep pyriform space.
• Significant differences in tissue resistance were observed between the two spaces (p < 0.05).
• Histology confirmed distinct boundaries, indicating suitability for stable filler placement.

Conclusions:

• The perialar space is a viable alternative for nasolabial fold volumization.
• This approach may enhance aesthetic outcomes and reduce filler migration and complications.
• Offers more stable facial rejuvenation results compared to existing techniques.