Microbubbles for Acoustically Mediated Drug Delivery to the Inner Ear
Charlotte Jeanneau1,2, Fabrice Micaletti1,2, Damien Fouan1
1Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253Tours, 37032, France.
Microbubble-assisted ultrasound offers a promising method for targeted inner ear drug delivery by overcoming the blood-labyrinth barrier. This review details microbubble formulations for enhanced acoustic delivery, crucial for treating inner ear conditions.
Area of Science:
- Otorhinolaryngology
- Biomedical Engineering
- Pharmacology
Background:
- The blood-labyrinth barrier (BLB) protects the inner ear but hinders therapeutic delivery.
- Developing effective inner ear drug delivery methods is crucial for treating auditory and vestibular disorders.
- Targeted delivery across the BLB remains a significant challenge.
Purpose of the Study:
- To review current microbubble (MB) formulations for inner ear drug delivery.
- To explore the potential of microbubble-assisted ultrasound for noninvasive therapeutic delivery.
- To highlight factors influencing the safety and efficacy of this delivery method.
Main Methods:
- Review of existing literature on microbubble formulations.
- Analysis of acoustically mediated drug delivery techniques.
- Focus on ultrasound and microbubble interactions for BLB permeation.
Main Results:
- Microbubble-assisted ultrasound is a promising noninvasive method for inner ear drug delivery.
- MB formulations and ultrasound parameters significantly impact delivery efficiency and safety.
- The review synthesizes current knowledge on MBs for acoustic delivery through the round window membrane.
Conclusions:
- Microbubble-assisted ultrasound represents an innovative approach to overcome BLB challenges.
- Optimized MB formulations are key to successful targeted inner ear drug delivery.
- Further research into MB properties and ultrasound parameters will advance therapeutic strategies.
More Related Videos
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
06:02Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
Published on: June 12, 2021
Related Concept Videos
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Drug Delivery: Enteral Route
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Anatomy of the Ear
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
