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Published on: September 12, 2020
Inpatient direct oral challenge for sulfa antibiotic allergy: improving care in immunocompromised hosts
Elise A Mitri1,2,3, Sara Vogrin1,2, Rebecca Hall2
1Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbournehttps://ror.org/01ej9dk98, Melbourne, VIC, Australia.
Abstract:
In this prospective cohort study, trimethoprim-sulfamethoxazole direct oral challenge (DOC) for hospitalized adults reporting a low-risk sulfa antibiotic allergy was safe with 75/76 (99%) inpatients delabeled. Within 90-days of DOC, immunocompromised patients were more likely to receive trimethoprim-sulfamethoxazole, compared with non-immunocompromised patients (adjusted OR 5.6 95% CI 1.3, 23.0).
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