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Detection of Helicobacter pylori Infection and Antibiotic Resistance via Stool Quantitative Polymerase Chain Reaction Analysis
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Vascular endothelial function in pediatric patients with Helicobacter pylori infection and its response to

Ebtehal Abdelhai1, Doaa El Amrousy1, Naglaa Abou Taira2

  • 1Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Journal of Pediatric Gastroenterology and Nutrition
|February 2, 2026
PubMed

Insights

Helicobacter pylori infection in children causes endothelial dysfunction and dyslipidemia. Eradication therapy significantly improved these markers, indicating a link between H. pylori and cardiovascular health in pediatric patients.

Area of Science:

  • Pediatric Gastroenterology
  • Cardiovascular Health
  • Infectious Diseases

Background:

  • Helicobacter pylori (H. pylori) infection is common in children.
  • Endothelial dysfunction and dyslipidemia are risk factors for cardiovascular disease.
  • The impact of H. pylori on endothelial function in children is not well understood.

Purpose of the Study:

  • To evaluate endothelial function in children with H. pylori infection using flow-mediated dilatation (FMD).
  • To assess the effect of H. pylori eradication therapy on endothelial function and lipid profiles.
  • To investigate the relationship between H. pylori infection, endothelial dysfunction, and cardiovascular risk factors.

Main Methods:

  • Sixty symptomatic children were divided into H. pylori-positive (n=30), H. pylori-negative (n=30), and healthy control (n=30) groups.
  • Blood tests included complete blood count, hs-CRP, and lipid profiles.
  • Endothelial function was measured by brachial artery FMD. H. pylori-positive patients received 2-week triple therapy and were reassessed after 3 months.

Main Results:

  • H. pylori-positive children showed significantly higher hs-CRP, cholesterol, triglycerides, and LDL, with lower hemoglobin, HDL, and FMD compared to H. pylori-negative and control groups (p<0.001).
  • After eradication therapy, responders demonstrated significant increases in hemoglobin, HDL, and FMD.
  • Successful eradication led to significant decreases in hs-CRP and lipid profiles (p<0.001). FMD correlated negatively with symptom duration, hs-CRP, cholesterol, and Sydney score, and positively with HDL.

Conclusions:

  • Children with H. pylori infection exhibit endothelial dysfunction and dyslipidemia.
  • Successful H. pylori eradication therapy significantly improves endothelial function and lipid profiles in children.
  • H. pylori infection is a modifiable risk factor for endothelial dysfunction and dyslipidemia in pediatric populations.
Abstract

Keywords:
childrendyslipidemiagastritis

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