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Longitudinal Changes in Left Ventricular Geometry After Kidney Transplantation and Their Implications on

Dong-Hyuk Cho1, Jun Gyo Gwon2, Jimi Choi3

  • 1Division of Cardiology, Department of Internal Medicine, Korea University Medicine, Seoul, Republic of Korea.

Kidney Medicine
|February 2, 2026
PubMed

Insights

Kidney transplantation improves hemodynamics but metabolic changes impact heart remodeling. Increased relative wall thickness after transplantation predicts major adverse cardiovascular events, highlighting the need for metabolic control.

Area of Science:

  • Nephrology
  • Cardiology
  • Metabolic Medicine

Background:

  • Cardiovascular disease is the leading cause of death post-kidney transplantation (KT).
  • Understanding metabolic and hemodynamic changes after KT is crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the impact of metabolic and hemodynamic changes on myocardial remodeling and clinical outcomes after KT.
  • To assess the association between echocardiographic changes and major adverse cardiovascular events (MACE).

Main Methods:

  • A multicenter observational prospective cohort study of 600 patients undergoing KT.
  • Echocardiography was performed before and 3 years after KT.
  • Cox proportional hazards models analyzed the association between echocardiographic changes and MACE.

Main Results:

  • Post-KT, triglyceride and HbA1c levels increased, while hemoglobin and systolic blood pressure improved.
  • Left ventricular end-diastolic dimension improved, but relative wall thickness (RWT) increased.
  • Increased RWT independently predicted MACE, while hemodynamic changes affected left ventricular size.

Conclusions:

  • Hemodynamic improvements post-KT are linked to reduced left ventricular size.
  • Better metabolic control correlates with improved heart wall thickness.
  • Optimizing metabolic control is key to enhancing cardiovascular outcomes after KT.
Abstract

Keywords:
Heart ventriclecardiovascular diseasehemodynamicskidney transplantationtriglycerides

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