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Implications of LINC01094 for human malignancies

Yan Wang1,2, Yang Yang1,3, Quanying Zhang1,3

  • 1Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang, Guangdong, China.

Peerj
|February 2, 2026
PubMed

Insights

Long non-coding RNA LINC01094 regulates cancer cell growth, invasion, and migration by affecting key signaling pathways. This review summarizes its oncogenic functions to guide future cancer management strategies.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • RNA Biology

Background:

  • Long non-coding RNAs (lncRNAs) are crucial regulators of gene expression in biological processes.
  • Aberrant lncRNA expression is linked to carcinogenesis and oncogenesis.
  • LINC01094 is a lncRNA implicated in various cancers, acting via competing endogenous RNA (ceRNA) mechanisms.

Purpose of the Study:

  • To review the multifaceted roles of LINC01094 in cancer biology.
  • To consolidate current knowledge on LINC01094's functions in tumor progression.
  • To highlight LINC01094's potential as a therapeutic target in human malignancies.

Main Methods:

  • Literature review of published studies on LINC01094.
  • Analysis of LINC01094's involvement in cancer cell signaling pathways.
  • Examination of LINC01094's impact on transcriptional regulatory networks.

Main Results:

  • LINC01094 acts as a ceRNA, modulating tumor cell growth, invasion, and migration.
  • It regulates critical pathways such as PI3K/AKT, PTEN/AKT, and Wnt/β-catenin.
  • LINC01094 exhibits oncogenic effects through transcriptional regulation, promoting cancer progression and metastasis.

Conclusions:

  • LINC01094 plays significant oncogenic roles in cancer development and metastasis.
  • Understanding LINC01094's functions offers insights for novel cancer management approaches.
  • Further research into LINC01094 could lead to innovative laboratory and clinical strategies for treating human cancers.
Keywords:
CancersClinical characteristicsGrowth and metastasisLINC01094Molecular mechanisms

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