Summary
Extended oral ampicillin therapy shows promise for treating pharyngeal gonorrhea. This multi-day regimen demonstrated a low failure rate, comparing favorably to current treatments for this common sexually transmitted infection.
Area of Science:
- Infectious Diseases
- Pharmacology
- Microbiology
Background:
- Single-dose oral ampicillin trihydrate is ineffective for pharyngeal gonorrhea.
- Evaluating extended ampicillin therapy is crucial for effective treatment options.
Purpose of the Study:
- To assess the efficacy of an extended oral ampicillin regimen for pharyngeal gonorrhea.
- To determine the failure rate of this novel therapeutic approach.
Main Methods:
- A regimen of 3.5g ampicillin trihydrate with probenecid on day 1, followed by 500mg ampicillin trihydrate QID for 2 days (total 7.5g).
- 101 patients received the extended therapy.
- Test-of-cure cultures were obtained within 35 days for 77 patients.
Main Results:
- A low treatment failure rate was observed, ranging from 1.3% to 3.9%.
- Three patients had positive test-of-cure cultures; two may have been reinfected.
- The regimen's efficacy compares favorably with existing therapies.
Conclusions:
- Extended oral ampicillin therapy is an effective treatment for pharyngeal gonorrhea.
- This regimen offers a viable alternative to current treatment standards.
- Further research may explore optimizing dosage and duration for improved outcomes.
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