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Ferritin as a predictive salivary marker for ECC-III.
Kinjal Vekariya1, Shantanu Choudhari1, Gadhiya Niraliben2
1Department of Pediatric Dentistry, Government Dental College and Hospital, Ahmedabad, India.
Salivary ferritin levels are significantly higher in children with severe early childhood caries (ECC-III). This finding suggests salivary ferritin can be a useful, non-invasive biomarker for assessing ECC severity and predicting its progression.
Area of Science:
- Pediatric Dentistry
- Biomarkers
- Oral Health
Background:
- Dental caries, particularly early childhood caries (ECC), is a widespread pediatric oral health issue.
- Saliva contains numerous biomarkers that can indicate oral health status.
- Ferritin, an iron-storage protein, is present in saliva and may correlate with dental caries.
Purpose of the Study:
- To investigate the correlation between salivary ferritin levels and the severity of early childhood caries (ECC-III) in young children.
- To evaluate the potential of salivary ferritin as a non-invasive biomarker for ECC.
Main Methods:
- Sixty children aged 4-5 years were divided into a caries-free control group and an ECC-III group (≥5 decayed, missing, or filled teeth).
- Salivary ferritin levels were quantified using a diagnostic kit.
- Statistical analyses were performed to compare ferritin levels between the groups.
Main Results:
- Children in the ECC-III group exhibited significantly higher salivary ferritin levels compared to the caries-free control group (p < 0.0001).
- A strong correlation was observed between elevated salivary ferritin and the presence of severe dental caries.
Conclusions:
- Salivary ferritin demonstrates potential as a simple and non-invasive biomarker for assessing the severity of early childhood caries.
- Measuring salivary ferritin may aid in predicting the progression of ECC in pediatric populations.
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