Life's Essential 8 and healthy longevity among people with and without cardiometabolic multimorbidity: A prospective

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Miao Huang1,2, Ru Fu1, Xiexiong Zhao1

  • 1Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.

American Journal of Preventive Cardiology
|February 2, 2026
PubMed

Insights

Improving cardiovascular health with Life's Essential 8 (LE8) significantly lowers mortality risk and extends life expectancy, even for individuals with multiple cardiometabolic diseases (CMM). Higher LE8 scores consistently correlate with better health outcomes.

Area of Science:

  • Cardiovascular Health
  • Public Health
  • Epidemiology

Background:

  • Cardiometabolic multimorbidity (CMM) presents a significant public health challenge, associated with increased mortality and reduced life expectancy.
  • Assessing cardiovascular health (CVH) through metrics like Life's Essential 8 (LE8) is crucial for understanding its impact on diverse patient groups.

Purpose of the Study:

  • To investigate the independent and combined effects of Life's Essential 8 (LE8) scores on mortality risk and life expectancy.
  • To analyze these impacts across different strata of cardiometabolic disease status, including no cardiometabolic diseases (CMD), single cardiometabolic disease (SCMD), and cardiometabolic multimorbidity (CMM).

Main Methods:

  • Utilized data from 264,675 UK Biobank participants.
  • Categorized participants into low, moderate, and high CVH levels based on LE8 scores.
  • Employed Cox proportional hazards and flexible parametric survival models to assess mortality risk and estimate life expectancy.

Main Results:

  • A 10-point increase in LE8 score was associated with a ~20% reduction in all-cause mortality risk across all disease groups.
  • Individuals with CMM and low CVH had a 6.49-fold increased mortality risk compared to CMD-free individuals with high CVH.
  • High CVH was linked to a 66.12% reduction in CMM-related mortality risk and significantly increased residual life expectancy.

Conclusions:

  • Higher LE8 scores are robustly associated with decreased mortality risk and enhanced residual life expectancy, irrespective of cardiometabolic disease status.
  • Improving cardiovascular health via LE8 is a viable strategy for mitigating mortality and improving longevity in the general population and those with CMM.
Abstract

Keywords:
Cardiometabolic multimorbidityCardiovascular healthLife expectancyLife’s Essential 8Mortality

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