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Updated: Feb 4, 2026

Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of ManganeseII Acetylacetonate
Published on: June 18, 2020
Manganese dioxide- and cobalt oxide-doped hydroxyapatite with curcumin for orthopedic and dental applications
Joel Pilli1,2, Gwenevere Gatto1,2, Sameer Jain1,3
1Sustainable Manufacturing and Tissue Engineering Laboratory, Department of Materials and Metallurgical Engineering, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA.
Abstract:
Due to their compositional similarities to bone, hydroxyapatite (HA)-based materials are used as bioactive ceramics for musculoskeletal repair. However, because of the lack of any inherent antibacterial properties, HA scaffolds have higher possibilities of post-surgical bacterial infections. The goal of this research is to fabricate alternate antibacterial and cytocompatible bone tissue engineering scaffolds using cobalt oxide (CoO)- and manganese dioxide (MnO2)-doped HA and plant-sourced curcumin from turmeric. Characterization results show no negative effects in phase and microstructure because of doping. When dopants and curcumin are combined, the antibacterial efficacy against S. aureus is ~ 95% after 24 h. The addition of dopants does not result in any cytotoxicity with the NIH3T3 cell line, and the bioactivity of this delivery system is confirmed in a physiological pH of 7.4. In summary, our findings provide an alternate method for manufacturing antibacterial scaffolds for orthopedic and dental applications employing curcumin-loaded CoO-MnO2-doped HA.
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