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Sign Test for Matched Pairs01:17

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The sign test for matched pairs offers a robust method for comparing two paired samples, often for the effects of an intervention in one of them. This method is very useful in situations where the underlying distribution of the data is unknown. The test compares two related samples—often pre- and post-treatment measurements on the same subjects—to determine if there are significant differences in their median values.
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Related Experiment Video

Updated: Feb 4, 2026

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
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Platelet lipidome alterations in septic shock: a matched case-control study.

Emma de Cartier d'Yves1, Melanie Dechamps1,2, Jérôme Ambroise3

  • 1Pole of Cardiovascular Research (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium.

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Summary

Septic shock significantly alters platelet lipids, impacting hemostasis and inflammation. These lipidomic changes correlate with thrombocytopenia severity, offering new insights into sepsis.

Keywords:
blood plateletcoagulopathyinflammationlipidomicsseptic shock

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Area of Science:

  • Biochemistry
  • Hematology
  • Sepsis Research

Background:

  • Platelets are crucial in hemostatic and inflammatory responses during septic shock.
  • Lipids are essential for platelet function, but their specific alterations in septic shock are not well understood.

Purpose of the Study:

  • To characterize platelet lipidomic changes in septic shock.
  • To investigate the association of these lipid alterations with disease severity.

Main Methods:

  • A matched case-control study involving 49 septic shock patients and 47 controls.
  • Untargeted lipidomics was used for platelet lipid profiling.
  • Exploration of associations between lipid changes, clinical data, and biomarkers.

Main Results:

  • Over 60% of annotated platelet lipids were significantly altered in septic shock.
  • Key alterations included reduced cholesteryl esters, sphingomyelins, lysophosphatidylcholines, ether-lipids, and increased ceramides.
  • Lipid changes correlated with thrombocytopenia, and lysophosphatidylcholine levels inversely correlated with disease severity (SOFA score).

Conclusions:

  • Septic shock causes significant platelet lipidome disruption, correlating with thrombocytopenia severity.
  • These widespread lipid changes impact multiple classes, exceeding those in other conditions.
  • Findings illuminate sepsis-driven effects on platelet lipid composition, inflammation, and coagulopathy.