Related Experiment Video
Updated: Feb 4, 2026
06:04
LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
Published on: April 4, 2016
11.7K
Platelet lipidome alterations in septic shock: a matched case-control study.
Emma de Cartier d'Yves1, Melanie Dechamps1,2, Jérôme Ambroise3
1Pole of Cardiovascular Research (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain (UCLouvain), Brussels, Belgium.
Research and Practice in Thrombosis and Haemostasis
|February 2, 2026
Summary
Septic shock significantly alters platelet lipids, impacting hemostasis and inflammation. These lipidomic changes correlate with thrombocytopenia severity, offering new insights into sepsis.
Area of Science:
- Biochemistry
- Hematology
- Sepsis Research
Background:
- Platelets are crucial in hemostatic and inflammatory responses during septic shock.
- Lipids are essential for platelet function, but their specific alterations in septic shock are not well understood.
Purpose of the Study:
- To characterize platelet lipidomic changes in septic shock.
- To investigate the association of these lipid alterations with disease severity.
Main Methods:
- A matched case-control study involving 49 septic shock patients and 47 controls.
- Untargeted lipidomics was used for platelet lipid profiling.
- Exploration of associations between lipid changes, clinical data, and biomarkers.
Main Results:
- Over 60% of annotated platelet lipids were significantly altered in septic shock.
- Key alterations included reduced cholesteryl esters, sphingomyelins, lysophosphatidylcholines, ether-lipids, and increased ceramides.
- Lipid changes correlated with thrombocytopenia, and lysophosphatidylcholine levels inversely correlated with disease severity (SOFA score).
Conclusions:
- Septic shock causes significant platelet lipidome disruption, correlating with thrombocytopenia severity.
- These widespread lipid changes impact multiple classes, exceeding those in other conditions.
- Findings illuminate sepsis-driven effects on platelet lipid composition, inflammation, and coagulopathy.
Related Concept Videos
01:17Sign Test for Matched Pairs
411
The sign test for matched pairs offers a robust method for comparing two paired samples, often for the effects of an intervention in one of them. This method is very useful in situations where the underlying distribution of the data is unknown. The test compares two related samples—often pre- and post-treatment measurements on the same subjects—to determine if there are significant differences in their median values.
To conduct the sign test, we first calculate the differences in...
To conduct the sign test, we first calculate the differences in...
411
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
471
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
471
01:30Alterations in Respiration II
1.8K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.8K
01:16Shock Waves
2.6K
While deriving the Doppler formula for the observed frequency of a sound wave, it is assumed that the speed of sound in the medium is greater than the source's speed through it. When this condition is breached, a shock wave occurs.
When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high...
When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high...
2.6K
01:06Altered States of Awareness
1.1K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.1K
01:09Wilcoxon Signed-Ranks Test for Matched Pairs
496
The Wilcoxon signed-rank test for matched pairs evaluates the null hypothesis by combining the ranks of differences with their signs. It essentially tests whether the median of the differences in a population of matched pairs is zero. Since the test incorporates more information than the sign test, it generally yields more trustable conclusions. This test also does not require the data to follow a normal distribution, but two conditions must be met for it to be applicable: (1) the data must...
496