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Precision Medicine in Disorders of Gut-Brain Interaction

Brian E Lacy1, Hasan Saleh2, David J Cangemi1

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida.

Gastroenterology & Hepatology
|February 2, 2026
PubMed

Insights

Precision medicine, which tailors treatments using patient-specific data, offers potential for disorders of gut-brain interaction (DGBIs). This approach can improve diagnosis and therapy for prevalent DGBIs like IBS.

Area of Science:

  • Gastroenterology
  • Genetics
  • Internal Medicine

Background:

  • Precision medicine leverages individual genetic, environmental, and lifestyle data for disease prevention, diagnosis, and treatment.
  • While established in oncology, precision medicine's application in disorders of gut-brain interaction (DGBIs) remains limited.
  • DGBIs affect 40% of the global population, including conditions like functional dyspepsia and irritable bowel syndrome, significantly impacting quality of life and healthcare systems.

Purpose of the Study:

  • To define precision medicine and differentiate it from personalized medicine.
  • To explore the potential application of precision medicine in managing DGBIs.
  • To outline a strategy for implementing precision medicine in DGBIs.

Main Methods:

  • Literature review defining precision medicine and its contrast with personalized medicine.
  • Discussion of current and potential uses of precision medicine in DGBIs.
  • Analysis of limitations and proposal of a strategic framework for precision medicine in DGBIs.

Main Results:

  • Precision medicine utilizes comprehensive patient data for tailored medical strategies.
  • Significant potential exists for precision medicine to enhance diagnosis and treatment of prevalent DGBIs.
  • Current implementation in DGBIs is minimal, necessitating strategic development.

Conclusions:

  • Precision medicine offers a promising avenue for advancing the care of DGBIs.
  • Overcoming limitations and developing strategic implementation are crucial for realizing precision medicine's benefits in DGBIs.
  • Further research and clinical integration are needed to harness precision medicine for improved DGBI patient outcomes.
Keywords:
Chronic constipationfunctional dyspepsiagenomicsirritable bowel syndromemetabolomicsprecision medicine

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