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Updated: Feb 4, 2026

Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets
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Genome-wide association study identifies three PNPLA3/SAMM50 SNPs associated with HCC development in non-viral liver

Xia-Rong Liu1, Tsai-Hsuan Yang1, Tung-Hung Su2,3

  • 1Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

JHEP Reports : Innovation in Hepatology
|February 2, 2026
PubMed
Summary

Genetic variants in PNPLA3/SAMM50 are linked to hepatocellular carcinoma (HCC) risk in individuals without viral hepatitis. These findings offer potential biomarkers for HCC risk stratification and precision prevention strategies.

Keywords:
Steatosisbiobanklong-term riskprospective cohortsusceptibility

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