Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Colloids03:22

Colloids

21.1K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
21.1K
Colloids and Suspensions01:17

Colloids and Suspensions

3.4K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
3.4K
Colloidal precipitates01:09

Colloidal precipitates

6.5K
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
6.5K
Fixed Action Patterns01:06

Fixed Action Patterns

17.7K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.7K
Patterns of Fever01:26

Patterns of Fever

3.9K
Before understanding the types and patterns of fever, it is essential to know its phases.
3.9K
Surface Tension and Surface Energy01:16

Surface Tension and Surface Energy

3.3K
When a paint brush is immersed in water, the bristles wave freely inside the water. When it is taken out, the bristles stick together. The reason behind this effect is surface tension.
Consider a beaker filled with liquid. The bulk molecules in the liquid experience equal attractive forces on all sides with the surrounding molecules. However, the surface molecules experience a net attractive force downward due to the bulk molecules. The surface of the liquid behaves like a stretched membrane,...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A pump-free microfluidic device for integrated multi-functional testing of tumor spheroids.

APL bioengineering·2026
Same author

CD59 drives diet-induced obesity and glucose intolerance, insulin resistance, and metabolic dysfunction-associated steatotic liver disease.

npj metabolic health and disease·2026
Same author

Gestational Ketosis Compromises Nephron Endowment and Long-Term Kidney Function in Offspring.

Journal of the American Society of Nephrology : JASN·2026
Same author

Spatial Relations between Coccoliths and Their Confining Membrane During Crystal Morphogenesis.

Journal of the American Chemical Society·2026
Same author

Bridging nanomechanics and bioenergetics of single mitochondria by atomic force microscopy.

Life science alliance·2026
Same author

Corrigendum to "The paradoxical protective effect of chronic stress on advanced Alzheimer's disease pathology". [Brain, Behav., Immun. 132 (2026) 106224].

Brain, behavior, and immunity·2026
Same journal

Tri-modal nanocatalytic microenvironment regulations for macrophage reprogramming and osteoporotic fracture healing promotion.

Materials today. Bio·2026
Same journal

Temporal-responsive hydrogels reprogramming energy metabolic pathway in the bone-angiogenic cascade for diabetic bone regeneration.

Materials today. Bio·2026
Same journal

Immunoregulatory strategies of MOF-based nanodrug delivery systems: Advances in cancer therapy applications and future perspectives.

Materials today. Bio·2026
Same journal

Biomimetic delivery of a STING agonist <i>via</i> tumor antigen-primed dendritic cell membrane nanovesicles for bladder cancer immunotherapy.

Materials today. Bio·2026
Same journal

Membrane-camouflaged metal-phenolic nanomedicines for the treatment of ischemic stroke via relieving oxidative stress and neuroinflammation.

Materials today. Bio·2026
Same journal

A DMAHDM-herbal hybrid gargle for orthodontic-associated complications via oral microbiota regulation, inflammation inhibition, and enamel protection.

Materials today. Bio·2026
See all related articles

Related Experiment Video

Updated: Feb 4, 2026

Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

10.5K

Colloid-patterned surfaces distinguish malignant mechanophenotypes.

Chalom Zemmour1,2, Mor Ozeri1, Ora T Cohen1

  • 1Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 91120, Jerusalem, Israel.

Materials Today. Bio
|February 2, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a label-free platform using colloidal topographies to measure cancer cell biophysical traits, revealing distinct adhesion and particle uptake patterns linked to metastasis. The method aids in identifying aggressive cancer cells for potential clinical use.

More Related Videos

Photodeposition of Pd onto Colloidal Au Nanorods by Surface Plasmon Excitation
06:58

Photodeposition of Pd onto Colloidal Au Nanorods by Surface Plasmon Excitation

Published on: August 15, 2019

7.9K
Plasma Lithography Surface Patterning for Creation of Cell Networks
05:58

Plasma Lithography Surface Patterning for Creation of Cell Networks

Published on: June 14, 2011

13.1K

Related Experiment Videos

Last Updated: Feb 4, 2026

Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

10.5K
Photodeposition of Pd onto Colloidal Au Nanorods by Surface Plasmon Excitation
06:58

Photodeposition of Pd onto Colloidal Au Nanorods by Surface Plasmon Excitation

Published on: August 15, 2019

7.9K
Plasma Lithography Surface Patterning for Creation of Cell Networks
05:58

Plasma Lithography Surface Patterning for Creation of Cell Networks

Published on: June 14, 2011

13.1K

Area of Science:

  • Biophysics
  • Cancer Biology
  • Materials Science

Background:

  • Accurate identification of aggressive cancer cells is crucial for effective treatment.
  • Metastatic progression involves complex cellular biophysical changes.
  • Existing methods for assessing cancer cell aggressiveness have limitations.

Purpose of the Study:

  • To develop and validate a label-free mechanophenotyping platform for identifying aggressive cancer cells.
  • To reveal biophysical traits, specifically adhesion and particle uptake, associated with metastatic potential.
  • To correlate these biophysical traits with cellular behavior and molecular pathways.

Main Methods:

  • Fabrication of controlled colloidal topographies on cell culture plates using polystyrene beads.
  • Measurement of cancer cell adhesion and particle uptake on these micro/nano-featured surfaces.
  • Utilizing atomic force microscopy (AFM) for force mapping and transcriptomic profiling for molecular analysis.

Main Results:

  • Metastatic cancer cells exhibit distinct patterns of increased particle uptake and stronger adhesion compared to primary tumor cells.
  • Adhesion differences were particle size-dependent and more pronounced on colloidal surfaces than flat substrates.
  • Lymphatically selected cells showed reduced adhesion but higher particle uptake, suggesting dynamic changes during metastasis.
  • Transcriptomic data revealed enrichment of adhesion and extracellular matrix (ECM)-remodeling pathways in adhesive metastatic cells.

Conclusions:

  • The developed platform provides functional signatures of metastatic potential by assessing label-free biophysical traits.
  • Mechanophenotyping via colloidal topography offers a novel approach for cancer cell classification and aggressiveness assessment.
  • This accessible technology holds promise for high-throughput and clinical applications in cancer diagnostics.