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Multi-modal deep-learning troponin prediction from electrocardiograms and demographic data.

Lukas Hilgendorf1,2,3, Pétur Pétursson1,4, Erik Andersson1,2

  • 1Institute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg, Sahlgrenska Academy, Vita stråket 15, Sahlgrenska sjukhuset, Gothenburg 41345, Sweden.

European Heart Journal. Digital Health
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PubMed
Summary

A new deep-learning model accurately predicts high-sensitivity troponin elevation using electrocardiograms (ECGs) and patient data. This AI tool aids in faster diagnosis of cardiac conditions like myocardial infarction during emergency room triage.

Keywords:
Acute myocardial infarctionBiomarkersElectrocardiogramEmergency cardiologyMachine learning

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Area of Science:

  • Cardiology
  • Artificial Intelligence
  • Medical Diagnostics

Background:

  • Electrocardiograms (ECGs) and troponin (Tn) testing are crucial for diagnosing cardiac conditions.
  • Early detection significantly improves patient outcomes in emergency care settings.

Purpose of the Study:

  • To develop and validate a deep-learning model for predicting high-sensitivity troponin (hs-Tn) elevation.
  • To enhance the chest-pain triage process by providing rapid diagnostic insights.

Main Methods:

  • A multi-modal deep-learning model was created, integrating ECG data, age, and sex.
  • The model was trained on a multi-center dataset of 35,821 ECGs from patients with chest pain or dyspnea.
  • External validation was performed using data from two emergency rooms.

Main Results:

  • The model achieved an internal area under the receiver operating characteristic (AUROC) of 0.8958.
  • External validation demonstrated a strong AUROC of 0.8765.
  • Saliency maps indicated the model focuses on relevant ECG segments like the ST-segment.

Conclusions:

  • The developed deep-learning model offers a novel approach to predicting hs-Tn elevation.
  • This predictive capability can significantly improve the speed and accuracy of acute myocardial infarction alerts.
  • Predicting troponin levels offers an objective label, enhancing diagnostic reliability in triage.