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Multi-modal deep-learning troponin prediction from electrocardiograms and demographic data
Lukas Hilgendorf1,2,3, Pétur Pétursson1,4, Erik Andersson1,2
1Institute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg, Sahlgrenska Academy, Vita stråket 15, Sahlgrenska sjukhuset, Gothenburg 41345, Sweden.
European Heart Journal. Digital Health
|February 2, 2026
Summary
A new deep-learning model accurately predicts high-sensitivity troponin elevation using electrocardiograms (ECGs) and patient data. This AI tool aids in faster diagnosis of cardiac conditions like myocardial infarction during emergency room triage.
Area of Science:
- Cardiology
- Artificial Intelligence
- Medical Diagnostics
Background:
- Electrocardiograms (ECGs) and troponin (Tn) testing are crucial for diagnosing cardiac conditions.
- Early detection significantly improves patient outcomes in emergency care settings.
Purpose of the Study:
- To develop and validate a deep-learning model for predicting high-sensitivity troponin (hs-Tn) elevation.
- To enhance the chest-pain triage process by providing rapid diagnostic insights.
Main Methods:
- A multi-modal deep-learning model was created, integrating ECG data, age, and sex.
- The model was trained on a multi-center dataset of 35,821 ECGs from patients with chest pain or dyspnea.
- External validation was performed using data from two emergency rooms.
Main Results:
- The model achieved an internal area under the receiver operating characteristic (AUROC) of 0.8958.
- External validation demonstrated a strong AUROC of 0.8765.
- Saliency maps indicated the model focuses on relevant ECG segments like the ST-segment.
Conclusions:
- The developed deep-learning model offers a novel approach to predicting hs-Tn elevation.
- This predictive capability can significantly improve the speed and accuracy of acute myocardial infarction alerts.
- Predicting troponin levels offers an objective label, enhancing diagnostic reliability in triage.
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