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Hematological Malignancies With Multiple Primary Cancers: A Rare Case Presentation
Soudamini Mahapatra1, Priyanka Samal1, Ashutosh Samal2
1Department of Clinical Hematology, Institute of Medical Sciences & Sum Hospital, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, Odisha, 751003, India, soa.ac.in.
Case Reports in Hematology
|February 2, 2026
Summary
This study highlights two distinct cases of multiple primary cancers in adult males. Optimal treatment for these complex cases necessitates a multidisciplinary approach and careful cancer staging.
Area of Science:
- Oncology
- Hematology
- Urology
Background:
- Multiple primary cancers involve two or more distinct primary malignancies in different patients.
- Optimal management of multiple primary cancers requires interdisciplinary collaboration.
Purpose of the Study:
- To present two unique cases of multiple primary cancers in adult males.
- To emphasize the importance of multidisciplinary team (MDT) discussion in managing complex oncological cases.
Main Methods:
- Case 1: A 53-year-old male with new-onset hematuria diagnosed with Precursor B-acute lymphoblastic leukemia (B-ALL) and noninvasive papillary urothelial neoplasm.
- Case 2: A 53-year-old male with recurrent anaplastic oligodendroglioma and newly diagnosed chronic myeloid neoplasm (CMN) in the chronic phase.
Main Results:
- Case 1: Diagnosis of concurrent Precursor B-ALL and low-grade papillary urothelial neoplasm.
- Case 2: Diagnosis of recurrent anaplastic oligodendroglioma (WHO Grade 3) and BCR-ABL1 p210 positive CMN in chronic phase.
Conclusions:
- The incidence of second primary malignancies is increasing due to improved cancer screening and survival.
- Accurate cancer staging and MDT consultation are crucial for determining the best therapeutic strategies.
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